734412112/11/202006/01/2021ValidatedValidated20/06/202508/01/2021Florence Carrouelhttp://admin-epid-prod2.inserm.fr/en/layout/set/print/content/view/full/90145http://admin-epid-prod2.inserm.fr/en/layout/set/print/content/view/full/90160http://admin-epid-prod2.inserm.fr/en/layout/set/print/ccontent/xml/(NodeId)/90145Effet de bains de bouche sur la charge virale salivaire de SARS-CoV-2Nasal and Salivary Detection of the SARS-CoV-2 Virus After Antiviral MouthrinsesBBCovidBBCovidCPP 2020.04.11 sept _20.04.06.46640, CNIL 2217601 v 0, ClinicalTrials.gov ID: NCT04352959CPP 2020.04.11 sept _20.04.06.46640, CNIL 2217601 v 0, ClinicalTrials.gov ID: NCT04352959Maladies infectieusesInfectious diseasesOuiYesCARROUELFlorenceLaboratory "Systemic Health Course", EA4129 Faculty of Medicine Laennec, 11 Rue Guillaume Paradin, 69372 LYON CEDEX 08 FRANCEflorence.carrouel@univ-lyon1.frLaboratory "Systemic Health Course", EA4129University Lyon 1CARROUELFlorenceLaboratory "Systemic Health Course", EA4129 Faculty of Medicine Laennec, 11 Rue Guillaume Paradin, 69372 LYON CEDEX 08 FRANCEflorence.carrouel@univ-lyon1.frLaboratory "Systemic Health Course", EA4129University Lyon 1NonNoLaboratory "Systemic Health Course", EA4129PublicLaboratory "Systemic Health Course", EA4129PublicBOMELEriceric.bomel@ezus.univ-lyon1.frBOMELEriceric.bomel@ezus.univ-lyon1.frAutresOthersDécrire l’évolution de la charge virale nasale et salivaire chez des patients probablement infectés par le Covid-19, effectuant pendant 7 jours des bains de bouche avec et sans antiviraux.Change from Baseline amount of SARS-CoV-2 in salivary samples at 7 days Quantitative PCR experiments will be performed and a quantitative analysis of the salivary samples will be madeAge : 18 ans – 70 ans. Diagnostic clinique d’infection Covid-19 par le médecin généraliste et hospitalier du patient Début des signes cliniques depuis moins de 48 heures. Confirmation virologique : pas nécessaire mais possible. Compréhension et acceptation de l’essai. Accord écrit de participation à l’essai• Age: 18-70 years • Clinical diagnosis of Covid-19 infection by the patient's general practitioner and hospital doctor • Clinical signs started less than 48 hours ago. • Virological confirmation: not necessary but possible. • Understanding and acceptance of the trial. • Written agreement to participate in the trialAdolescence (13 à 18 ans)Adulte (19 à 24 ans)Adulte (25 à 44 ans)Adulte (45 à 64 ans)Personnes âgées (65 à 79 ans)Adolescence (13 to 18 years)Adulthood (19 to 24 years)Adulthood (25 to 44 years)Adulthood (45 to 64 years)Elderly (65 to 79 years)Sujets maladesSick populationI - Certaines maladies infectieuses et parasitairesI - Certain infectious and parasitic diseasesMasculinFémininMaleWomanNationalNational20202020< 500 individus< 500 individuals175Collecte des données terminéeData collection completedDonnées cliniquesDonnées biologiquesClinical dataBiological dataExamen médicalMedical registrationeCRFNonNohttp://admin-epid-prod2.inserm.fr/en/layout/set/print/content/download/106727/4014187/version/1/file/Carrouel et al CMI 2021.pdfUse of an antiviral mouthwash as a barrier measure in the SARS-CoV-2 transmission in adults with asymptomatic to mild COVID-19: a multicentre, randomized, double-blind controlled trialhttp://admin-epid-prod2.inserm.fr/en/layout/set/print/content/download/106728/4014192/version/1/file/Carrouel et al Trial 2020.pdfSalivary and Nasal Detection of the SARS- CoV-2 Virus After Antiviral Mouthrinses (BBCovid): A structured summary of a study protocol for a randomised controlled trialhttp://admin-epid-prod2.inserm.fr/en/layout/set/print/content/download/106729/4014197/version/1/file/Carrouel et al viruses 2021.pdfPerformance of Self-Collected Saliva Testing Compared with Nasopharyngeal Swab Testing for the Detection of SARS-CoV-2http://admin-epid-prod2.inserm.fr/en/layout/set/print/content/download/100602/3901260/version/1/file/Carrouel et al Trial 2020.pdf